Jun
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UBC Researchers Find Stroke Death Channel
June 13, 2006 |
New therapies for stroke patients may soon be possible, thanks to a discovery made by a team of 
University of British Columbia neuroscience researchers who have found a new stroke death channel — the conduit through which key chemicals are lost from brain cells during stroke, causing the cell death that disables stroke victims.
The findings were published recently in Science and will be the subject of an editorial in next month’s issue of Nature Reviews Neuroscience.
“We’ve known for 40 years about chemicals flowing out of cells after stroke, but nobody knew the exact process — so we went looking for the death channel. And we found it,” says Roger Thompson, a UBC Psychiatry post-doctoral Fellow who made the discovery, along with graduate student Ning Zhou and Psychiatry Prof. Brian MacVicar, all members of the Brain Research Centre at UBC Hospital and of Vancouver Coastal Health Research Institute.
The researchers found, in animal models, that brain cell membranes were disrupted at the site of gap junction hemichannels. Gap junctions are connections that allow molecules and ions to flow between cells. Junctions are composed of two hemichannels that bridge the intercellular space. UBC Researchers Find Stroke Death Channel - UBC Public Affairs
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